Griffithsin inhibits porcine reproductive and respiratory syndrome virus infection in vitro
Identifieur interne : 000E17 ( Main/Exploration ); précédent : 000E16; suivant : 000E18Griffithsin inhibits porcine reproductive and respiratory syndrome virus infection in vitro
Auteurs : Lan Li ; Xiaoning Tian ; Jin Chen ; Pengcheng Li ; Qisheng Zheng ; Jibo HouSource :
- Archives of Virology [ 0304-8608 ] ; 2018.
Abstract
Porcine reproductive and respiratory syndrome virus (PRRSV) is a pathogen that severely disrupts swine production. Despite sustained efforts, the disease is still endemic, with high mortality and morbidity. New antiviral strategies to control PRRSV are needed. Griffithsin, a red algal lectin, has potent antiviral effect on several human enveloped viruses, but this effect has not been demonstrated on PRRSV. Here, we first tested the
Url:
DOI: 10.1007/s00705-018-4029-x
PubMed: 30220033
PubMed Central: 7087274
Affiliations:
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sort="Li, Lan" uniqKey="Li L" first="Lan" last="Li">Lan Li</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0017 5204</institution-id><institution-id institution-id-type="GRID">grid.454840.9</institution-id><institution>National Research, Center of Engineering and Technology for Veterinary Biologicals,</institution><institution>Jiangsu Academy of Agricultural Sciences,</institution></institution-wrap>Nanjing, 210014 Jiangsu People’s Republic of China</nlm:aff><wicri:noCountry code="subfield">210014 Jiangsu People’s Republic of China</wicri:noCountry></affiliation></author><author><name sortKey="Tian, Xiaoning" sort="Tian, Xiaoning" uniqKey="Tian X" first="Xiaoning" last="Tian">Xiaoning Tian</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9750 7019</institution-id><institution-id institution-id-type="GRID">grid.27871.3b</institution-id><institution>College of Veterinary Medicine,</institution><institution>Nanjing Agricultural University,</institution></institution-wrap>Nanjing, 210095 Jiangsu People’s Republic of China</nlm:aff><wicri:noCountry code="subfield">210095 Jiangsu People’s Republic of China</wicri:noCountry></affiliation></author><author><name sortKey="Chen, Jin" sort="Chen, Jin" uniqKey="Chen J" first="Jin" last="Chen">Jin Chen</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0017 5204</institution-id><institution-id institution-id-type="GRID">grid.454840.9</institution-id><institution>National Research, Center of Engineering and Technology for Veterinary Biologicals,</institution><institution>Jiangsu Academy of Agricultural Sciences,</institution></institution-wrap>Nanjing, 210014 Jiangsu People’s Republic of China</nlm:aff><wicri:noCountry code="subfield">210014 Jiangsu People’s Republic of China</wicri:noCountry></affiliation></author><author><name sortKey="Li, Pengcheng" sort="Li, Pengcheng" uniqKey="Li P" first="Pengcheng" last="Li">Pengcheng Li</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0017 5204</institution-id><institution-id institution-id-type="GRID">grid.454840.9</institution-id><institution>National Research, Center of Engineering and Technology for Veterinary Biologicals,</institution><institution>Jiangsu Academy of Agricultural Sciences,</institution></institution-wrap>Nanjing, 210014 Jiangsu People’s Republic of China</nlm:aff><wicri:noCountry code="subfield">210014 Jiangsu People’s Republic of China</wicri:noCountry></affiliation></author><author><name sortKey="Zheng, Qisheng" sort="Zheng, Qisheng" uniqKey="Zheng Q" first="Qisheng" last="Zheng">Qisheng Zheng</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0017 5204</institution-id><institution-id institution-id-type="GRID">grid.454840.9</institution-id><institution>National Research, Center of Engineering and Technology for Veterinary Biologicals,</institution><institution>Jiangsu Academy of Agricultural Sciences,</institution></institution-wrap>Nanjing, 210014 Jiangsu People’s Republic of China</nlm:aff><wicri:noCountry code="subfield">210014 Jiangsu People’s Republic of China</wicri:noCountry></affiliation></author><author><name sortKey="Hou, Jibo" sort="Hou, Jibo" uniqKey="Hou J" first="Jibo" last="Hou">Jibo Hou</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0017 5204</institution-id><institution-id institution-id-type="GRID">grid.454840.9</institution-id><institution>National Research, Center of Engineering and Technology for Veterinary Biologicals,</institution><institution>Jiangsu Academy of Agricultural Sciences,</institution></institution-wrap>Nanjing, 210014 Jiangsu People’s Republic of China</nlm:aff><wicri:noCountry code="subfield">210014 Jiangsu People’s Republic of China</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff3">Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, 225009 Jiangsu People’s Republic of China</nlm:aff><wicri:noCountry code="subfield">225009 Jiangsu People’s Republic of China</wicri:noCountry></affiliation></author></analytic><series><title level="j">Archives of Virology</title><idno type="ISSN">0304-8608</idno><idno type="eISSN">1432-8798</idno><imprint><date when="2018">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="Par1">Porcine reproductive and respiratory syndrome virus (PRRSV) is a pathogen that severely disrupts swine production. Despite sustained efforts, the disease is still endemic, with high mortality and morbidity. New antiviral strategies to control PRRSV are needed. Griffithsin, a red algal lectin, has potent antiviral effect on several human enveloped viruses, but this effect has not been demonstrated on PRRSV. Here, we first tested the <italic>in vitro</italic> antiviral activity of Griffithsin against PRRSV. Griffithsin exerted strong saccharide-dependent antiviral activity against PRRSV, probably through interactions with glycans on the surface of PRRSV that interfered with virus entry. Furthermore we revealed that Griffithsin’s action on PRRSV involved blocking viral adsorption, and it had no effect on viral penetration. Besides Our findings also suggested that Griffithsin may interfere with cell-to-cell spread to prevent virus transmission. 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Li</name><name sortKey="Tian, Xiaoning" sort="Tian, Xiaoning" uniqKey="Tian X" first="Xiaoning" last="Tian">Xiaoning Tian</name><name sortKey="Zheng, Qisheng" sort="Zheng, Qisheng" uniqKey="Zheng Q" first="Qisheng" last="Zheng">Qisheng Zheng</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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